Model description

Using an Albumin-Cre conditional gene knockout model, groups of mice are bred to have liver-specific knockout of the Myc oncogene (MYC), the carbohydrate-responsive element binding protein (ChREBP) gene (MLXIPL), or both. Four groups of normal liver samples were collected: wild-type liver (WL), Myc-KO liver (MKL), ChREBP-KO liver (CKL), and double-KO liver (DKL).

In each of these four groups, hepatoblastoma (HB) liver tumors were induced with a tail-vein-injection of a sleeping beauty vector containing β-catenin and YAP. After 12 weeks, HB tumor samples were collected from each of the four groups: wild-type tumors (WT), Myc-KO tumors (MKT), ChREBP-KO tumors (CKT), and double-KO tumors (DKT).